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[原发性高血压患者的红细胞钠-锂逆向转运和钠-钾协同转运]

[RBC Na(+)-Li+ countertransport and Na(+)-K+ cotransport in patients with essential hypertension].

作者信息

Zhang G S

机构信息

Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Second Medical University.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 1993 Aug;21(4):204-6, 252.

PMID:8194429
Abstract

The correlation analyses were performed in 60 patients with essential hypertension (EHT) and 77 normotensives (NT) between RBC Na(+)-Li(+)-countertransport (SLC), Na(+)-K+ cotransport (SPT) and blood pressure, Quetelet index (QI), serum insulin, blood lipids, uric acid, blood glucose, etc. Results showed: (1) The SLC in EHT patients were higher, while SPT lower than NT group; (2) The difference between EHT and NT group was much prominent in SLC of male, while prominent in SPT of female; (3) There was no sex difference in SLC and SPT, and the SLC was correlated positively with QI3; (4) By multiple variants stepwise regression analysis, the SLC was shown to be associated positively with systolic and diastolic blood pressure; while the SPT inversely with systolic blood pressure. It suggests that SLC and SPT exert an independent effect on blood pressure.

摘要

对60例原发性高血压(EHT)患者和77例血压正常者(NT)进行红细胞钠-锂逆向转运(SLC)、钠-钾协同转运(SPT)与血压、体重指数(QI)、血清胰岛素、血脂、尿酸、血糖等之间的相关性分析。结果显示:(1)EHT患者的SLC较高,而SPT低于NT组;(2)EHT组与NT组之间的差异在男性的SLC中更为显著,而在女性的SPT中更为显著;(3)SLC和SPT不存在性别差异,且SLC与QI3呈正相关;(4)通过多元逐步回归分析,显示SLC与收缩压和舒张压呈正相关;而SPT与收缩压呈负相关。这表明SLC和SPT对血压有独立影响。

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