Wahrburg U, Martin H, Schulte H, Walek T, Assmann G
Institute for Arteriosclerosis Research, University of Münster, Germany.
Eur J Clin Nutr. 1994 Mar;48(3):172-9.
To investigate the effects of two kinds of decaffeinated coffee on serum lipid profiles in healthy young adults.
Randomized controlled study with three study groups and a parallel design, consisting of two consecutive periods.
Outpatient clinical research center in a university clinic.
119 healthy students (60 male, 59 female) who were selected after a screening. All completed the study. Blood samples of three subjects (1 male, 2 female) were excluded from evaluation due to later diagnosed genetic anomalies of lipid metabolism.
All subjects consumed 750-1000 ml of caffeinated filtered coffee per day for a 2 week wash-in period. During the 6 week test period one group continued drinking the caffeinated coffee, while the two other groups consumed different kinds of decaffeinated coffee.
Consumption of both types of decaffeinated coffee did not lead to any significant changes in serum total and LDL cholesterol, triglycerides and apolipoprotein B. Furthermore, there were no significant differences in the reactions between the three groups. The diet did not change during the study.
Switch from regular to decaffeinated coffee had no cholesterol-elevating effects, irrespective of the type of coffee.
研究两种脱咖啡因咖啡对健康年轻成年人血清脂质谱的影响。
随机对照研究，有三个研究组，采用平行设计，包括两个连续阶段。
大学诊所的门诊临床研究中心。
119名健康学生（60名男性，59名女性），经筛选后入选。所有人均完成了研究。由于后来诊断出脂质代谢的遗传异常，三名受试者（1名男性，2名女性）的血样被排除在评估之外。
在为期2周的导入期内，所有受试者每天饮用750 - 1000毫升含咖啡因的过滤咖啡。在为期6周的测试期内，一组继续饮用含咖啡因的咖啡，而另外两组饮用不同种类的脱咖啡因咖啡。
饮用两种脱咖啡因咖啡均未导致血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯和载脂蛋白B发生任何显著变化。此外，三组之间的反应没有显著差异。研究期间饮食没有改变。
从普通咖啡转换为脱咖啡因咖啡不会产生升高胆固醇的作用，无论咖啡类型如何。
