Kenig M, Abraham E P
J Gen Microbiol. 1976 May;94(1):37-45. doi: 10.1099/00221287-94-1-37.
The dipeptide antibiotic bacilysin is active against a wide range of bacteria and against Candida albicans. Its C-terminal amino acid, anticapsin, is a very poor antibacterial agent. The activities of both substances are strongly dependent on the nature of the culture medium. In a minimal medium the minimum inhibitory concentration for bacilysin with E. coli B is 10(-3) mug ml(-1). The action of bacilysin amino acids. With several bacteria, bacilysin-resistant mutants are found in unusually large numbers. It is suggested that peptide and amino acid transport systems play a role in these phenomena. The antimicrobial action of bacilysin is also inhibited by glucosamine and N-acetylglucosamine. This antibiotic may therefore interfere with glucosamine synthesis and thus with the synthesis of microbial cell walls.
二肽抗生素杆菌溶素对多种细菌及白色念珠菌具有活性。其C端氨基酸抗荚膜素是一种非常低效的抗菌剂。这两种物质的活性都强烈依赖于培养基的性质。在基本培养基中，杆菌溶素对大肠杆菌B的最低抑菌浓度为10^(-3)微克/毫升。杆菌溶素氨基酸的作用。在几种细菌中，发现了数量异常多的对杆菌溶素耐药的突变体。有人认为肽和氨基酸转运系统在这些现象中起作用。杆菌溶素的抗菌作用也受到氨基葡萄糖和N-乙酰氨基葡萄糖的抑制。因此，这种抗生素可能会干扰氨基葡萄糖的合成，进而干扰微生物细胞壁的合成。
