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An enzyme aggregate involved in the biosynthesis of aromatic amino acids in Bacillus subtilis. Its possible function in feedback regulation.一种参与枯草芽孢杆菌芳香族氨基酸生物合成的酶聚集体。其在反馈调节中的可能功能。
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Gene-enzyme relationships of aromatic acid biosynthesis in Bacillus subtilis.枯草芽孢杆菌中芳香酸生物合成的基因-酶关系
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Antimicrobial activities and antagonists of bacilysin and anticapsin.杆菌溶素和抗荚膜素的抗菌活性及拮抗剂
J Gen Microbiol. 1976 May;94(1):37-45. doi: 10.1099/00221287-94-1-37.
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Transport and metabolism of bacilysin and other peptides by suspensions of Staphylococcus aureus.金黄色葡萄球菌悬浮液对杆菌溶素及其他肽的转运与代谢
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9
Construction of a kit of reference strains for rapid genetic mapping in Bacillus subtilis 168.构建用于枯草芽孢杆菌168快速基因定位的参考菌株试剂盒。
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枯草芽孢杆菌合成杆菌溶素的过程分支自芳香族氨基酸途径的预苯酸。

Synthesis of bacilysin by Bacillus subtilis branches from prephenate of the aromatic amino acid pathway.

作者信息

Hilton M D, Alaeddinoglu N G, Demain A L

机构信息

Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

J Bacteriol. 1988 Jan;170(1):482-4. doi: 10.1128/jb.170.1.482-484.1988.

DOI:10.1128/jb.170.1.482-484.1988
PMID:3121591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC210674/
Abstract

Previously characterized mutants of Bacillus subtilis 168 were analyzed for the accumulation of the antibiotic bacilysin in culture broths and for the presence of bacilysin synthetase in cell extracts. All aro mutants tested were deficient in bacilysin biosynthesis but had synthetase activity. Mutants with lesions in tyrA and pheA produced normal levels of bacilysin, suggesting that prephenate is the primary metabolic precursor of bacilysin.

摘要

对先前已鉴定的枯草芽孢杆菌168突变体进行了分析，检测其在培养液中抗生素杆菌溶素的积累情况以及细胞提取物中杆菌溶素合成酶的存在情况。所有测试的aro突变体在杆菌溶素生物合成方面均有缺陷，但具有合成酶活性。tyrA和pheA有损伤的突变体产生正常水平的杆菌溶素，这表明预苯酸是杆菌溶素的主要代谢前体。