Cantini F, Bellandi F, Niccoli L, Di Munno O
II U.O. di Medicina Generale, USL n.9, Prato, Presidio Ospedaliero.
Minerva Med. 1994 Mar;85(3):97-100.
The aim of this study is to evaluate the effectiveness of fluoxetin associated with cyclobenzaprine vs cyclobenzaprine in the treatment of fibromyalgia. Twenty-one females with fibromyalgia were randomly assigned to 2 groups: group A (11 patients) was treated over 12 weeks with fluoxetin (20 mg/die) and cyclobenzaprine (10 mg/die), group B with cyclobenzaprine (10 mg/die). Basally and after 12 weeks patient self-assessment of pain, number of painful tender points, tender points index and morning stiffness were evaluated. The study has shown a significant improvement of the examined parameters in both treatment groups; however the comparison between the two groups showed a greater effectiveness, statistically significant, of the treatment with Fluoxetin associated with cyclobenzaprine.
本研究旨在评估氟西汀联合环苯扎林与环苯扎林治疗纤维肌痛的疗效。21名患有纤维肌痛的女性被随机分为两组：A组（11名患者）接受为期12周的氟西汀（20毫克/天）和环苯扎林（10毫克/天）治疗，B组接受环苯扎林（10毫克/天）治疗。在治疗开始时及12周后，对患者的疼痛自我评估、疼痛压痛点数量、压痛点指数和晨僵情况进行评估。研究表明，两个治疗组的各项检查参数均有显著改善；然而，两组之间的比较显示，氟西汀联合环苯扎林治疗的有效性更高，具有统计学意义。
