Fanos V, Khoory B J, Danieli D, Padovani E M
Clinica Pediatrica, Università di Verona, Italia.
Pediatr Med Chir. 1993 Nov-Dec;15(6):579-82.
Infections caused by Gram-positive bacteria, particularly in neonatal patients, have increased dramatically over the past 10 years. In the present study 19 newborns (7 at term, 12 preterm) with proven staphylococcal infection were treated with teicoplanin, after a previous ineffective antibiotic treatment (amikacin+oxacillin or third-generation cephalosporin). Bacterial eradication and clinical cure were achieved in all neonates. No adverse events related to the drug occurred. No significant change was observed in serial biochemical and hematological tests. Our results suggest that teicoplanin is highly effective and safe in neonatal staphylococcal infections.
革兰氏阳性菌引起的感染，尤其是在新生儿患者中，在过去10年里急剧增加。在本研究中，19例确诊为葡萄球菌感染的新生儿（7例足月儿，12例早产儿）在先前使用抗生素（阿米卡星+奥沙西林或第三代头孢菌素）治疗无效后，接受了替考拉宁治疗。所有新生儿均实现了细菌清除和临床治愈。未发生与该药物相关的不良事件。连续的生化和血液学检查未观察到显著变化。我们的结果表明，替考拉宁在新生儿葡萄球菌感染中高效且安全。
