Anastasio G D, Little J M, Robinson M D, Pettice Y L, Leitch B B, Norton H J
Department of Family Practice, Carolinas Medical Center, Charlotte, NC 28232-2861.
Pharmacotherapy. 1994 Mar-Apr;14(2):229-34.
To determine the relationship among compliance, side effects, and self-reported outcome for patients in an erythromycin trial.
A retrospective analysis of data from a multicenter, prospective, single-blind, randomized trial.
Five metropolitan ambulatory care offices.
The 252 adults (> 18 yrs) were prescribed oral erythromycin 1.0 g/day (base equivalent) for infectious disorders.
Subjects received erythromycin for 10 days and reported compliance, drug efficacy, and side effects in a daily diary. Compliance was measured by tablet count.
A negative correlation was found between gastrointestinal symptom severity score and percentage of tablets taken (p < 0.001). A significant positive correlation was seen between compliance and outcome (p < 0.001). Subjects who took greater than 80% of the drug achieved the treatment goal more frequently than those taking 80% or less (94% vs 59%, p < 0.001).
Side effects of erythromycin adversely affected compliance. Compliance had a positive effect on self-reported outcome.
确定在一项红霉素试验中患者的依从性、副作用和自我报告结果之间的关系。
对一项多中心、前瞻性、单盲、随机试验的数据进行回顾性分析。
五个大都市门诊护理办公室。
252名成年人（>18岁）因感染性疾病被处方口服红霉素1.0克/天（碱基当量）。
受试者接受红霉素治疗10天，并在每日日记中报告依从性、药物疗效和副作用。依从性通过药片计数来衡量。
胃肠道症状严重程度评分与服药片数百分比之间呈负相关（p<0.001）。依从性与结果之间呈显著正相关（p<0.001）。服用超过80%药物的受试者比服用80%或更少药物的受试者更频繁地实现治疗目标（94%对59%，p<0.001）。
红霉素的副作用对依从性有不利影响。依从性对自我报告结果有积极影响。
