快速抗原检测在疑似链球菌性咽炎治疗中与抗生素使用的依从性的相关性。
Association between use of rapid antigen detection tests and adherence to antibiotics in suspected streptococcal pharyngitis.
机构信息
Primary Care Centre Jaume I, Tarragona, University Rovira i Virgili, Spain.
出版信息
Scand J Prim Health Care. 2010 Mar;28(1):12-7. doi: 10.3109/02813431003669301.
OBJECTIVE
Few studies have analysed adherence to antibiotic treatment in pharyngitis. The aim of this study was to evaluate the association of rapid antigen detection tests (RADT) and treatment adherence among patients 18 years of age or over with pharyngitis treated with different antibiotic regimens.
DESIGN
Prospective study from 2003 to 2008.
SETTING
Office-based physician practices. Intervention. The adherence of patients prior to the use of RADTs - no test was available until mid-2006 - was compared with the adherence associated with the use of RADTs.
SUBJECTS
Patients with suspected streptococcal pharyngitis.
MAIN OUTCOME MEASURES
Patient adherence was assessed by electronic monitoring. The adherence outcomes considered were antibiotic-taking adherence, correct dosing, and good timing adherence during at least 80% of the antibiotic course.
RESULTS
A total of 196 patients were recruited. The percentage of container openings was 77.9%+/-17.7%, being significantly higher for patients in whom the RADTs were performed compared with those in whom this test was not undertaken (80.1% vs. 70.8% for thrice-daily antibiotic regimens and 88.1% vs. 76.5% for twice-daily regimens; p < 0.01). The other variables of adherence were also better among patients undergoing RADT in both those who took at least 80% of the pills (71.3% vs. 42.2%; p < 0.001) as well as those with good timing adherence (52.5% vs. 32.8%; p < 0.01). Furthermore, correct dosing was always greater when the patient had undergone an RADT.
CONCLUSION
Adherence to antibiotic treatment is higher when an RADT is carried out at the consultation prior to administration of antibiotic treatment.
目的
很少有研究分析过咽炎患者对抗生素治疗的依从性。本研究旨在评估不同抗生素方案治疗的 18 岁及以上咽炎患者使用快速抗原检测（RADT）前后的治疗依从性。
设计
2003 年至 2008 年的前瞻性研究。
地点
门诊医生诊所。
干预措施
在 2006 年年中之前，RADT 不可用，因此比较了患者在使用 RADT 之前和之后的治疗依从性。
研究对象
疑似链球菌性咽炎患者。
主要观察指标
通过电子监测评估患者的依从性。考虑的依从性结果包括抗生素服用依从性、正确剂量和至少 80%的抗生素疗程中良好的时间依从性。
结果
共招募了 196 名患者。容器开口的百分比为 77.9%+/-17.7%，进行 RADT 的患者显著高于未进行该检测的患者（每日 3 次抗生素方案为 80.1% vs. 70.8%，每日 2 次抗生素方案为 88.1% vs. 76.5%；p < 0.01）。在接受 RADT 的患者中，其他依从性变量也更好，包括至少服用 80%的药物的患者（71.3% vs. 42.2%；p < 0.001）和具有良好时间依从性的患者（52.5% vs. 32.8%；p < 0.01）。此外，当患者接受 RADT 时，正确剂量总是更大。
结论
在开始抗生素治疗前的就诊时进行 RADT 可提高抗生素治疗的依从性。
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