Mkrtumova N A, Alekseeva R M, Buraia T I, Baslerova Iu A, Kraĭnova S I, Kandror V I
Probl Endokrinol (Mosk). 1994 Mar-Apr;40(2):39-42.
Clinico-hormonal examinations of 19 patients with juvenile struma revealed in many of them signs of latent hypothyrosis (increased age-specific level of blood serum TTH level and hyperergic reaction to TRH). Incubation of thyrocytes isolated from perinodular tissue of patients with euthyroid nodular goiter with IgG isolated from the blood serum of patients with juvenile struma resulted in a reliably lower content of cAMP in the cells than after thyrocyte incubation with IgG isolated from the blood serum of 9 healthy donors. This is indicative of the presence of thyroblocking antibodies in the blood serum of patients with juvenile struma. Though no correlation could be traced between the tested immunoglobulin activity, on the one hand, and blood serum TTH level and struma size, on the other, one may propose a contribution of thyroblocking antibodies to the pathogenesis of juvenile struma.
对19例青少年甲状腺肿患者进行的临床激素检查显示，其中许多人有潜在甲状腺功能减退的迹象（血清促甲状腺激素水平的年龄特异性升高以及对促甲状腺激素释放激素的过敏反应）。将从甲状腺功能正常的结节性甲状腺肿患者的结节周围组织中分离出的甲状腺细胞与从青少年甲状腺肿患者血清中分离出的IgG一起孵育，结果发现细胞内cAMP的含量比用9名健康供体血清中分离出的IgG孵育甲状腺细胞后可靠地降低。这表明青少年甲状腺肿患者血清中存在甲状腺阻断抗体。尽管一方面所检测的免疫球蛋白活性与另一方面血清促甲状腺激素水平和甲状腺肿大小之间未发现相关性，但仍可认为甲状腺阻断抗体在青少年甲状腺肿的发病机制中起作用。
