László F A, Varga C, Papp A, Pávó I, Fahrenholz F
Department of Comparative Physiology, József Attila University of Sciences, Szeged, Hungary.
Acta Physiol Hung. 1993;81(2):137-45.
A study was carried out how the sexual difference influences the increase in blood pressure (BP) induced by arginine vasopressin (AVP), and how the binding characteristics of 3H-labelled AVP on membranes prepared from the vascular bed were affected. After the administration of various doses of AVP, a significantly higher BP increase was observed in male rats than in females. The vasopressor effect of AVP was reduced in males following orchidectomy or administration of the antiandrogen cyproterone acetate. The vasopressin (VP) antagonist d(CH2)5Tyr(Me)AVP diminished the BP response to AVP in both sexes. The plasma AVP level was found to be much higher in males than in females, but it was decreased to the level of females after orchidectomy. The density of AVP-binding sites in the aorta membrane preparation was smaller in females, and in orchidectomized or cyproterone acetate-treated male rats than in the control males. The results demonstrate that testosterone upregulates the number of AVP-binding sites, leading to an increase in the pressor response to AVP in the rat vascular bed.
开展了一项研究，以探讨性别差异如何影响精氨酸加压素（AVP）诱导的血压（BP）升高，以及3H标记的AVP在血管床制备的膜上的结合特性如何受到影响。给予不同剂量的AVP后，雄性大鼠的血压升高明显高于雌性大鼠。去势或给予抗雄激素醋酸环丙孕酮后，雄性大鼠中AVP的升压作用降低。加压素（VP）拮抗剂d(CH2)5Tyr(Me)AVP可减弱两性对AVP的血压反应。发现雄性大鼠的血浆AVP水平远高于雌性大鼠，但去势后其降至雌性大鼠的水平。雌性大鼠、去势或醋酸环丙孕酮处理的雄性大鼠主动脉膜制剂中AVP结合位点的密度低于对照雄性大鼠。结果表明，睾酮上调了AVP结合位点的数量，导致大鼠血管床对AVP的升压反应增加。
