Kónya L, Kékesi V, Nagy S J, Fehér J
2nd Department of Medicine, Semmelweis University, Medical School, Budapest, Hungary.
Acta Physiol Hung. 1993;81(3):219-28.
Open chest dogs undergoing 30-min occlusion of the left anterior descending coronary artery (LAD), followed by 20-min reperfusion, received silibinin (2 mg/kg body weight), allopurinol (100 mg for two days as pretreatment, 20 mg/kg body weight during ischemia and reperfusion), superoxide dismutase (SOD, 5 and 0.5 mg/kg body weight, starting from the last minute of ischemia over 6 min). Control and treated dogs were comparable with respect to myocardial regional contractile force (strain gauge), malondialdehyde (MDA) and creatinine kinase (CK) levels of sinus coronarius blood samples, heart rate, and blood pressure. Allopurinol and large doses of SOD produced significant improvement in contractility and decreased MDA levels, which might suggest free radical mediated reactions during reperfusion.
开胸犬接受左冠状动脉前降支（LAD）30分钟闭塞，随后20分钟再灌注，给予水飞蓟宾（2毫克/千克体重）、别嘌呤醇（预处理两天，每天100毫克，缺血和再灌注期间20毫克/千克体重）、超氧化物歧化酶（SOD，5毫克/千克体重和0.5毫克/千克体重，从缺血最后一分钟开始持续6分钟）。对照犬和治疗犬在心肌局部收缩力（应变计）、冠状窦血样丙二醛（MDA）和肌酸激酶（CK）水平、心率及血压方面具有可比性。别嘌呤醇和大剂量SOD使收缩力显著改善，MDA水平降低，这可能提示再灌注期间存在自由基介导的反应。
