Rapaccini G L, Pompili M, Caturelli E, Fusilli S, Trombino C, Gomes V, Squillante M M, Castelvetere M, Aliotta A, Grattagliano A
Istituto di Clinica Medica, Universita Cattolica del Sacro Cuore, Roma.
Am J Gastroenterol. 1994 Jun;89(6):898-902.
The aims of this study were to evaluate the typing accuracy of smear cytology and microhistology and of their association in the diagnosis of hepatocellular carcinoma arising in liver cirrhosis, and to analyze the usefulness of smear cytology in the diagnosis of well-differentiated neoplasms.
One hundred sixty patients with hepatocellular carcinoma underwent an ultrasound-guided fine-needle biopsy, providing material for cytological and histological study. In 73 patients, a double biopsy with noncutting and cutting needles was performed (double-needle group), whereas in the remaining 87, a single biopsy with cutting needle was carried out (single-needle group).
In the whole population examined, smear cytology, microhistology, and their association, provided the diagnosis of hepatocellular carcinoma in 128 (80%), 98 (61%), and 144 (90%) cases, respectively. The double-needle and the single-needle groups did not differ significantly as to typing accuracy. Smear cytology correctly diagnosed 54 of 64 neoplasms classified histologically as well-differentiated.
Our results show that both smear cytology and microhistology should be applied immediately, when diagnosing hepatocellular carcinoma arising in liver cirrhosis, and that smear cytology is effective in the diagnosis of well-differentiated neoplasms.
本研究旨在评估涂片细胞学和微组织学的分型准确性及其在肝硬化肝细胞癌诊断中的相关性，并分析涂片细胞学在高分化肿瘤诊断中的实用性。
160例肝细胞癌患者接受超声引导下细针穿刺活检，获取用于细胞学和组织学研究的材料。73例患者采用非切割针和切割针进行双重活检（双针组），其余87例采用切割针进行单次活检（单针组）。
在整个研究人群中，涂片细胞学、微组织学及其联合检测分别在128例（80%）、98例（61%）和144例（90%）病例中诊断出肝细胞癌。双针组和单针组在分型准确性方面无显著差异。涂片细胞学正确诊断了64例组织学分类为高分化的肿瘤中的54例。
我们的结果表明，在诊断肝硬化肝细胞癌时，应立即应用涂片细胞学和微组织学，且涂片细胞学在高分化肿瘤的诊断中有效。
