Kaminski C A, Robbins M S, Weibley R E
Department of Pharmacotherapy and Research, Tampa General Hospital, Florida.
Ann Emerg Med. 1994 Jun;23(6):1371-4. doi: 10.1016/s0196-0644(94)70364-7.
We describe severe sertraline intoxication in a child after accidental ingestion. Sertraline is a new antidepressant that has potent and selective inhibition of neuronal serotonin reuptake. Drug company-sponsored research has suggested little toxicity for this compound. Our patient exhibited prolonged tachycardia, hypertension, hallucinations, coma, hyperthermia, tremors of all extremities, and skin flushing. Clinicians should consider the possibility of serotonin syndrome among patients with similar clinical features and a recent history of sertraline or other serotonergic agent ingestion.
我们描述了一名儿童意外摄入舍曲林后发生的严重中毒情况。舍曲林是一种新型抗抑郁药，对神经元5-羟色胺再摄取具有强效和选择性抑制作用。制药公司赞助的研究表明该化合物毒性较小。我们的患者出现了持续性心动过速、高血压、幻觉、昏迷、高热、四肢震颤和皮肤潮红。临床医生对于具有类似临床特征且近期有舍曲林或其他5-羟色胺能药物摄入史的患者，应考虑血清素综合征的可能性。
