On the genesis of granulosa-cell ovarian tumors. Experimental data.

The ovaries and ovarian tumors induced in albino virgin mice of lines A and CC-57 by intravaginal treatment with different blastomogenic substances, such as polyurethan; 7,12-dimethylbenz-(alpha)anthracene; 8-hydroxyquinoline and synestrol, were studied histologically. 330 cases were under study, including 78 as control. The granulosa elements of ovarian follicles were found to be involved in the processes of epithelial transformation and tumorogenesis. Pretumor changes are reported to be under study in 56 cases, granulosa-cell tumors or proliferates morphologically identical to them -- in 26 cases. The data presented show close relations of the peculiarities of differentiation as well as proliferative processes in the epithelium of the women genitals and the ovarian granulosa tissue.