Klarr J M, Bhatt-Mehta V, Donn S M
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor.
Am J Perinatol. 1994 Mar;11(2):91-3. doi: 10.1055/s-2007-994563.
A single 30 mg intravenous dose of labetalol given 20 minutes prior to cesarean delivery at 35 weeks of gestation for severe pregnancy-induced hypertension was associated with symptoms of beta-adrenergic blockade (hypoglycemia, bradycardia, hypotension) in preterm twins. The infants were subsequently found to have therapeutic labetalol concentrations (180 and 150 ng/mL) in umbilical cord blood. The pharmacology of transplacental labetalol is reviewed and potential mechanisms for neonatal beta-adrenergic blockade are discussed.
