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母亲使用拉贝洛尔治疗对新生儿的不良影响。

Adverse neonatal effects of maternal labetalol treatment.

作者信息

Crooks B N, Deshpande S A, Hall C, Platt M P, Milligan D W

机构信息

Newcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne.

出版信息

Arch Dis Child Fetal Neonatal Ed. 1998 Sep;79(2):F150-1. doi: 10.1136/fn.79.2.f150.

Abstract

Two infants with features of severe beta adrenergic blockade, pericardial effusions, and myocardial hypertrophy were born to mothers receiving long term treatment with oral labetalol for hypertension in pregnancy. Labetalol was implicated in the aetiology of these problems. Pericardial effusion and myocardial hypertrophy have not been associated with labetalol toxicity in neonates.

摘要

两名患有严重β-肾上腺素能阻滞、心包积液和心肌肥厚症状的婴儿,其母亲在孕期因高血压接受了长期口服拉贝洛尔治疗。这些问题的病因被认为与拉贝洛尔有关。心包积液和心肌肥厚与新生儿拉贝洛尔毒性并无关联。

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本文引用的文献

1
Neonatal adrenergic blockade following single dose maternal labetalol administration.
Am J Perinatol. 1994 Mar;11(2):91-3. doi: 10.1055/s-2007-994563.
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Effect of labetalol infusion on uterine and fetal hemodynamics and fetal cardiac function.
Eur J Obstet Gynecol Reprod Biol. 1993 Oct;51(2):111-7. doi: 10.1016/0028-2243(93)90022-5.
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Side effects of labetalol in newborn infants.拉贝洛尔在新生儿中的副作用。
Br J Obstet Gynaecol. 1983 Sep;90(9):876. doi: 10.1111/j.1471-0528.1983.tb09333.x.
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The effect of maternal labetalol on the newborn infant.
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Acta Obstet Gynecol Scand. 1992 Feb;71(2):145-7. doi: 10.3109/00016349209007974.

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