GATA-1在急性成红细胞白血病中表达。

GATA-1 is expressed in acute erythroblastic leukaemia.

作者信息

Ekert H, Sievers E L, Tan A, Martin D I, Smith F O, Barnard D, Bernstein I D

机构信息

Royal Children's Hospital, Melbourne, Victoria, Australia.

出版信息

Br J Haematol. 1994 Feb;86(2):410-2. doi: 10.1111/j.1365-2141.1994.tb04755.x.

DOI:10.1111/j.1365-2141.1994.tb04755.x

PMID:8199039

Abstract

Previous studies have demonstrated the expression of GATA-1 (a DNA-binding nuclear protein) in erythrocytes, megakaryocytes, eosinophils, basophils, mast cells, early marrow progenitor cells and in mouse and human erythroid leukaemia cell lines. We studied 31 bone marrow specimens from patients with acute myeloid leukaemia (AML) for GATA-1 expression by reverse transcriptase/polymerase chain reaction (RT/PCR) analysis. GATA-1 expression was detected in all of the patients with erythroleukaemia, and in one of nine patients with megakaryoblastic leukaemia, but absent from 17 patients with French-American-British (FAB) M1-5 leukaemia. In AML, GATA-1 expression is indicative of differentiation to the erythroid and possibly megakaryocytic lineages, analogous to its expression in normal haemopoiesis.

摘要

先前的研究已证实GATA-1（一种DNA结合核蛋白）在红细胞、巨核细胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、早期骨髓祖细胞以及小鼠和人类红系白血病细胞系中均有表达。我们通过逆转录酶/聚合酶链反应（RT/PCR）分析，研究了31例急性髓系白血病（AML）患者骨髓标本中GATA-1的表达情况。在所有红白血病患者以及9例巨核细胞白血病患者中的1例中检测到了GATA-1表达，但17例法美英（FAB）M1-5白血病患者中未检测到该表达。在AML中，GATA-1表达表明向红系及可能的巨核细胞系分化，这与其在正常造血过程中的表达情况类似。