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乙醇作为恒河猴经口途径的阳性强化物:固定比率反应的维持。

Ethanol as a positive reinforcer via the oral route for rhesus monkeys: maintenance of fixed-ratio responding.

作者信息

Henningfield J E, Meisch R A

出版信息

Pharmacol Biochem Behav. 1976 Apr;4(4):473-5. doi: 10.1016/0091-3057(76)90066-6.

DOI:10.1016/0091-3057(76)90066-6
PMID:819942
Abstract

Two rhesus monkeys were required to emit 1 to 16 responses (FR 1, 2, 4, 8, and 16) per 0.5 ml delivery of either 8% (w/v( ethanol or water. Ethanol had been established as an effective reinforcer via the oral route in an earlier experiment [4]. At FR 16, responding maintained by ethanol clearly exceeded responding maintained by water for both monkeys. The volume of ethanol intake per session remained nearly constant from FR 1 to FR 16, however, the volume of water consumed per session decreased when FR 16 was required.

摘要

两只恒河猴被要求在每0.5毫升8%(重量/体积)乙醇或水的输送过程中做出1至16次反应(固定比率分别为1、2、4、8和16)。在早期实验中,乙醇已被确定为经口服途径有效的强化物[4]。在固定比率为16时,两只猴子中由乙醇维持的反应明显超过由水维持的反应。从固定比率1到16,每次实验中乙醇的摄入量基本保持不变,然而,当要求固定比率为16时,每次实验中消耗的水量减少。

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引用本文的文献

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Psychopharmacology (Berl). 1995 Aug;120(3):341-6. doi: 10.1007/BF02311182.
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J Exp Anal Behav. 1988 Jul;50(1):75-86. doi: 10.1901/jeab.1988.50-75.
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