Tamura K, Kimura Y, Tamura T, Kitashiro S, Izuoka T, Tsuji H, Iwasaka T, Inada M
Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Coron Artery Dis. 1994 Mar;5(3):267-73. doi: 10.1097/00019501-199403000-00013.
We investigated the effects of a platelet-activating-factor antagonist TCV-309, an antagonist of metabolites of ischemia, on arrhythmias and functional recovery during in-situ reperfusion in dogs.
Open-chest anesthetized dogs were subjected to ligation of the left anterior coronary artery. Ischemia was maintained for 20 min after which reperfusion was allowed. A cardiac surface ECG was recorded continuously with the II limb lead. Monophasic action potential, left ventricular segment shortening measured by sonomicrometer, and left ventricular pressure were recorded simultaneously under atrial pacing (group A, n = 14). In a second group of dogs, TCV-309 (1 mg/kg) was administered before coronary artery occlusion (group B, n = 12). The hearts were constantly paced through the right atrium at 120 beats/min throughout all experiments. Measurements were continuously obtained from before drug administration to 30 min after reperfusion.
The 90% repolarization time of monophasic action potentials in group B revealed significant recovery compared with group A until the fifth minute after reperfusion (P < 0.02). Reduction of severe ventricular arrhythmias was observed during reperfusion in group B (P < 0.05). The percentage segment shortening and left ventricular pressure did not differ significantly between the groups.
The platelet-activating-factor antagonist had beneficial effects on arrhythmias but not on functional recovery during reperfusion after brief coronary artery occlusion in situ in dogs.
我们研究了血小板活化因子拮抗剂TCV - 309（一种缺血代谢产物拮抗剂）对犬原位再灌注期间心律失常和功能恢复的影响。
对开胸麻醉的犬进行左冠状动脉结扎。缺血维持20分钟后进行再灌注。用II导联连续记录心脏表面心电图。在心房起搏下同时记录单相动作电位、用超声心动图仪测量的左心室节段缩短以及左心室压力（A组，n = 14）。在第二组犬中，在冠状动脉闭塞前给予TCV - 309（1 mg/kg）（B组，n = 12）。在所有实验过程中，通过右心房以120次/分钟的频率持续起搏心脏。从给药前到再灌注后30分钟连续进行测量。
与A组相比，B组单相动作电位的90%复极时间在再灌注后第5分钟前显示出显著恢复（P < 0.02）。在B组再灌注期间观察到严重室性心律失常减少（P < 0.05）。两组之间节段缩短百分比和左心室压力无显著差异。
血小板活化因子拮抗剂对犬原位短暂冠状动脉闭塞后再灌注期间的心律失常有有益作用，但对功能恢复无作用。
