Koynova R, Caffrey M
Department of Chemistry, Ohio State University, Columbus 43210-1173.
Chem Phys Lipids. 1994 Jan;69(1):1-34. doi: 10.1016/0009-3084(94)90024-8.
LIPIDAT is a computerized database providing access to the wealth of information scattered throughout the literature concerning synthetic and biologically derived polar lipid polymorphic and mesomorphic phase behavior. Here, a review of the LIPIDAT data subset referring to hydrated phosphatidylethanolamines (PE) is presented together with an analysis of these data. The PE subset represents 14% of all LIPIDAT records. It includes data collected over a 38-year period and consists of 1511 records obtained from 203 articles in 35 different journals. An analysis of the data in the subset has allowed us to identify trends in synthetic PE phase behavior reflecting changes in lipid chain length, chain unsaturation (number, isomeric type and position of double bonds), chain asymmetry and branching, type of chain-glycerol linkage (ether vs. ester) and headgroup modification. Also included is a summary of the data concerning the effect of pH, stereochemical purity, and different additives such as salts, saccharides, alcohols, amino adds and alkanes on PE phase behavior. Information on the phase behavior of biologically derived PE is also presented. This review includes 236 references.
LIPIDAT是一个计算机化数据库，可提供分散于文献中的有关合成及生物衍生的极性脂质多晶型和介晶相行为的大量信息。本文呈现了对LIPIDAT数据子集中关于水合磷脂酰乙醇胺（PE）的数据回顾以及对这些数据的分析。PE子集占LIPIDAT所有记录的14%。它包含了38年期间收集的数据，由从35种不同期刊的203篇文章中获取的1511条记录组成。对该子集中数据的分析使我们能够确定合成PE相行为的趋势，这些趋势反映了脂质链长度、链不饱和度（双键的数量、异构类型和位置）、链不对称性和分支、链 - 甘油连接类型（醚键与酯键）以及头部基团修饰的变化。其中还包括了关于pH值、立体化学纯度以及不同添加剂（如盐、糖类、醇类、氨基酸和烷烃）对PE相行为影响的数据总结。文中还介绍了生物衍生PE的相行为信息。这篇综述包含236篇参考文献。
