Sablińska B, Kietlińska Z, Zieliński J
Department of Gynaecological Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Warsaw, Poland.
Eur J Gynaecol Oncol. 1993;14 Suppl:146-51.
Surgery combined with chemotherapy was applied in 34 out of 178 patients (19.1%) with GTD during treatment at the Institute of Oncology in Warsaw in the years 1977-1989. This mode of treatment was used twice as often in patients with MTD (Metastatic Tumour Disease) (31.6%) than in those with NMTD (Non Metastatic Tumour Disease) (14.2%). All 34 patients, who were operated on, had hysterectomy and 3 of them thoracotomy also. The most common indication for surgery was the chemoresistance of the disease, which had been stated in 53% of all treated surgically. All the patients with NMTD and those with good prognosis MTD, treated by combination of chemotherapy and surgery were cured, which confirms the efficacy of adjuvant surgery in these groups of patients. The role of surgery in patients with high-risk MTD is limited because of disseminated disease, frequently seen in this group.
1977年至1989年期间，华沙肿瘤研究所对178例妊娠滋养细胞疾病（GTD）患者中的34例（19.1%）采用了手术联合化疗的治疗方法。这种治疗方式在转移性肿瘤疾病（MTD）患者中（31.6%）的使用频率是在非转移性肿瘤疾病（NMTD）患者中（14.2%）的两倍。所有接受手术的34例患者均进行了子宫切除术，其中3例还进行了开胸手术。手术最常见的指征是疾病的化疗耐药性，在所有接受手术治疗的患者中，这一情况占53%。所有接受化疗联合手术治疗的NMTD患者以及预后良好的MTD患者均治愈，这证实了辅助手术在这些患者群体中的有效性。由于该组患者中经常出现播散性疾病，手术在高危MTD患者中的作用有限。
