Das G D
Virchows Arch B Cell Pathol. 1976 May 26;20(4):287-98. doi: 10.1007/BF02890347.
The whole heads of 6 days old rats were exposed to 150R of X-ray irradiation to induce cell-death in the external granular layer of the cerebellum. The animals were sacrificed in a developmental sequence, and the tissue obtained from the cerebellum was prepared for electron microscopy. On the basis of the cytological criteria established for the macrophages in the cerebellum of the normal animals, characteristics of the resting and reactive macrophages and their transformation from one state to the other in the experimental animals are described. In their reactive state the macrophages showed hypertrophic and nuclear changes which were found identical to those seen in the reactive microglial elements. Issues pertaining to the ultrastructural characteristics of the macrophages, their endogenous presence in the developing cerebellum, and their transformation into the microglia cells are discussed.
将6日龄大鼠的整个头部暴露于150伦琴的X射线照射下，以诱导小脑外颗粒层中的细胞死亡。按照发育顺序处死动物，并将从小脑获得的组织制备用于电子显微镜检查。根据为正常动物小脑中的巨噬细胞确立的细胞学标准，描述了实验动物中静止和反应性巨噬细胞的特征以及它们从一种状态转变为另一种状态的情况。在反应状态下，巨噬细胞表现出肥大和核变化，这些变化与在反应性小胶质细胞成分中观察到的变化相同。讨论了与巨噬细胞的超微结构特征、它们在发育中小脑中的内源性存在以及它们向小胶质细胞的转化有关的问题。
