Ferreiro J A
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905.
Hum Pathol. 1994 May;25(5):522-4. doi: 10.1016/0046-8177(94)90125-2.
Expression of CD30 antigen using the monoclonal antibody Ber-H2 was investigated in 52 testicular tumors: pure seminoma (19 cases), pure embryonal carcinoma (eight cases), and mixed germ cell tumors (25 cases). None of the seminomas expressed Ber-H2, whereas seven of eight pure embryonal carcinomas contained this antigen. In mixed germ cell tumors Ber-H2 was present in none of 10 seminomatous components, none of seven yolk sac tumor components, and 20 of 24 embryonal carcinoma components. Teratomatous elements (16 cases) failed to stain with Ber-H2. Also, foci of intratubular germ cell neoplasia (ITGCN) (31 cases) failed to express Ber-H2. Ber-H2 is useful in distinguishing embryonal carcinoma from seminoma and yolk sac tumor. The failure of expression of Ber-H2 in ITGCN, as in seminoma, supports the close relationship of seminoma with ITGCN.
运用单克隆抗体Ber-H2对52例睾丸肿瘤进行了CD30抗原表达情况的研究，这些肿瘤包括：纯精原细胞瘤（19例）、纯胚胎癌（8例）以及混合性生殖细胞肿瘤（25例）。所有精原细胞瘤均未表达Ber-H2，而8例纯胚胎癌中有7例含有该抗原。在混合性生殖细胞肿瘤中，10个精原细胞瘤成分均未出现Ber-H2，7个卵黄囊瘤成分也均未出现，而24个胚胎癌成分中有20个出现了Ber-H2。畸胎瘤成分（16例）未被Ber-H2染色。此外，管内生殖细胞肿瘤（ITGCN）灶（31例）也未表达Ber-H2。Ber-H2有助于鉴别胚胎癌与精原细胞瘤及卵黄囊瘤。与精原细胞瘤一样，ITGCN中Ber-H2表达缺失，这支持了精原细胞瘤与ITGCN的密切关系。
