Kaar T K, O'Brien M, Duggan P F, Mullen G B
Cork Regional Hospital, Wilton.
Ir J Med Sci. 1994 Mar;163(3):126-7. doi: 10.1007/BF02965970.
A prospective study of the serum levels of unfractionated creatine phosphokinase (CPK) in 69 consecutive elderly patients undergoing surgery for hip fracture is reported. Serum unfractionated CPK levels were measured on admission, on the evening following surgery and daily for the first five days post-operatively. All of the CPK levels measured on admission were within the normal range for this laboratory. A gradual rise in CPK levels followed surgery. On the evening following surgery 75% of values were greater than the upper limit of the normal reference range. The peak values were seen on day 1 post-operatively but 25% of values were still less than the reference maximum. A gradual decline was seen after this and at day 5 post operatively 50% of values were within the normal reference range. A single unfractionated CPK determination is not of diagnostic benefit in the post-operative period in elderly patients with hip fracture. However, patients with intracapsular and intertrochanteric fractures do not show elevation of unfractionated CPK levels prior to surgery.
本文报告了一项对69例连续接受髋部骨折手术的老年患者血清总肌酸磷酸激酶（CPK）水平的前瞻性研究。在入院时、术后当晚以及术后头五天每天测量血清总CPK水平。所有入院时测量的CPK水平均在该实验室的正常范围内。CPK水平在手术后逐渐升高。术后当晚，75%的测量值高于正常参考范围的上限。峰值出现在术后第1天，但仍有25%的测量值低于参考最大值。此后逐渐下降，术后第5天，50%的测量值在正常参考范围内。对于老年髋部骨折患者，单次测定血清总CPK在术后并无诊断价值。然而，囊内骨折和转子间骨折患者在手术前血清总CPK水平并未升高。
