Grunst J, Dietze G, Wicklmayr M, Hoppe F, Mehnert H
Z Ernahrungswiss. 1975 Dec;14(4):259-67. doi: 10.1007/BF02025863.
15 min. after intravenous administration of fructose (10 g/5 min, 0,5 g/kg/h) the hepatic uric acid production in healthy volunteers increased from 0,07 mg/100 g X min to 0,52 mg/100 g X min. After one hour the enhanced uric acid production was 0,3 mg 100 g X min. The enhanced uric acid production was accompanied by an increased hepatic phosphate uptake. The highest value was 13 mumol/100 g X min. During the control period the liver released small amounts of phosphate into the hepatic vein. The increased hepatic uric acid output correlated with an enhanced renal clearance, therefore the peripheral venous uric acid concentrations remained unchanged.
静脉注射果糖（10克/5分钟，0.5克/千克/小时）15分钟后，健康志愿者的肝脏尿酸生成量从0.07毫克/100克×分钟增加到0.52毫克/100克×分钟。1小时后，尿酸生成量增加至0.3毫克/100克×分钟。尿酸生成增加的同时，肝脏对磷酸盐的摄取也增加。最高值为13微摩尔/100克×分钟。在对照期，肝脏向肝静脉释放少量磷酸盐。肝脏尿酸输出增加与肾脏清除率提高相关，因此外周静脉尿酸浓度保持不变。
