Rowlands B J, Giddings A E, Clark R G
Br J Surg. 1977 Jun;64(6):424-7. doi: 10.1002/bjs.1800640614.
Eighteen patients undergoing elective abdominal surgery had pre- and postoperative carbohydrate infusion tests with glucose, fructose or sorbitol. All three substrates produced significant hyperlactataemia postoperatively, the elevations of plasma lactate with fructose and sorbitol infusion being significantly greater than with glucose. Plasma uric acid was unchanged but there were moderate falls in plasma phosphate postoperatively. Intravenous nutritional regimens containing fructose and sorbitol may potentiate the development of harmful metabolic acidoses in 'at risk' patients and should always be used cautiously. Glucose is the carbohydrate calorie source of choice.
18例接受择期腹部手术的患者在术前和术后进行了葡萄糖、果糖或山梨醇的碳水化合物输注试验。所有三种底物在术后均产生了显著的高乳酸血症，果糖和山梨醇输注后血浆乳酸的升高显著高于葡萄糖。血浆尿酸未发生变化，但术后血浆磷酸盐有适度下降。含有果糖和山梨醇的静脉营养方案可能会使“高危”患者有害代谢性酸中毒的发生风险增加，应始终谨慎使用。葡萄糖是首选的碳水化合物热量来源。
