伴有浆细胞样分化和多克隆丙种球蛋白病的恶性淋巴瘤。
Malignant lymphoma with plasmacytoid differentiation and polyclonal gammopathy.
作者信息
Guardia J, Pedreira J D, Vidal M T, Roca A
出版信息
Acta Haematol. 1976;55(6):346-53. doi: 10.1159/000208039.
Two patients are presented with lymphadenopathy, hepatosplenomegaly and infiltration of the bone marrow with plasmocytoid cells in whom an important heterogeneous hyperimmunoglobulinemia was detected (3.18 and 5.85 g/100/ml). Autopsy showed widespread poorly differentiated lymphocytic lymphoma with plasmocytoid differentiation in the first case and a well differentiated lymphocytic lymphoma with plasmocytoid differentiation involving lymph nodes, marrow, spleen, liver and kidney in the second case. High concentrations of IgM and IgG were detected in lymph node and spleen homogenates from this case. After splenectomy and cyclophosphamide the immunoglobulins decreased. It is suggested that both cases had a malignant lymphoma with plasmocytoid differentiation and polyclonal gammopathy.
本文报告了两名患者，他们均有淋巴结病、肝脾肿大以及骨髓浆细胞样细胞浸润，并检测到显著的异质性高免疫球蛋白血症（分别为3.18和5.85g/100ml）。尸检显示，第一例为广泛的低分化淋巴细胞淋巴瘤伴浆细胞样分化，第二例为高分化淋巴细胞淋巴瘤伴浆细胞样分化，累及淋巴结、骨髓、脾脏、肝脏和肾脏。在该病例的淋巴结和脾脏匀浆中检测到高浓度的IgM和IgG。脾切除和环磷酰胺治疗后，免疫球蛋白水平下降。提示这两例均为伴有浆细胞样分化的恶性淋巴瘤和多克隆丙种球蛋白病。
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