佩罗尼氏病患者血清中抗弹性蛋白抗体水平升高。

Increased serum levels of anti-elastin antibodies in patients with Peyronie's disease.

作者信息

Stewart S, Malto M, Sandberg L, Colburn K K

机构信息

Department of Urology, Loma Linda Veterans Administration Hospital, California.

出版信息

J Urol. 1994 Jul;152(1):105-6. doi: 10.1016/s0022-5347(17)32828-8.

DOI:10.1016/s0022-5347(17)32828-8

PMID:8201639

Abstract

The cause of Peyronie's disease is unknown. Immunological mechanisms in the pathogenesis have been previously suggested. Antibodies to elastin are present in all individuals. However, abnormal serum levels of anti-tropoelastin (reflecting elastin synthesis) and anti-alpha-elastin (reflecting elastin destruction) are seen in a variety of autoimmune diseases. We show that patients with Peyronie's disease have higher levels of antibodies to tropoelastin (p < 0.047) and alpha-elastin (p < 0.012) than age-matched controls, suggesting an increase in elastin synthesis and breakdown, respectively. These findings suggest the presence of autoimmune mechanisms in the pathogenesis of Peyronie's disease, which may have future diagnostic and therapeutic implications.

摘要

佩罗尼氏病的病因尚不清楚。此前曾有人提出发病机制中的免疫机制。所有个体体内都存在抗弹性蛋白抗体。然而，在多种自身免疫性疾病中可观察到抗原弹性蛋白（反映弹性蛋白合成）和抗α-弹性蛋白（反映弹性蛋白破坏）的血清水平异常。我们发现，与年龄匹配的对照组相比，佩罗尼氏病患者的抗原弹性蛋白抗体（p < 0.047）和抗α-弹性蛋白抗体（p < 0.012）水平更高，这分别表明弹性蛋白合成和分解增加。这些发现提示佩罗尼氏病发病机制中存在自身免疫机制，这可能对未来的诊断和治疗具有启示意义。