Colburn K K, Kelly G T, Malto M C, Sandberg L B, Boucek R J
Department of Medicine, Loma Linda University, California.
Clin Rheumatol. 1992 Jun;11(2):206-10. doi: 10.1007/BF02207958.
Serum antibodies to native (tropo) and denatured (alpha) elastins appear to correlate with the production and breakdown respectively of elastic tissue. Elastin may be degraded as a part of autoimmune diseases. This possibility was tested by measuring IgG antibodies to tropo- and alpha-elastins by ELISA in the sera of 111 patients with a variety of connective tissue diseases compared with 18 healthy individuals. Anti-alpha-elastin antibodies were significantly higher in sera from 18 scleroderma patients than from healthy controls (p less than 0.008). Conversely, anti-tropoelastin antibody levels for scleroderma patients (p less than 0.03) and for patients with a variety of other connective tissue diseases (p less than 0.02) were lower than in healthy controls. Low antibody levels to native elastin and high levels of antibodies to denatured elastin suggest a low synthesis: degradation ratio for elastin in scleroderma. Scleroderma may be a unique model for elastin turnover because of its heretofore unrecognized accelerated elastolysis.
针对天然（原弹性蛋白）和变性（α-弹性蛋白）弹性蛋白的血清抗体似乎分别与弹性组织的生成和分解相关。弹性蛋白可能作为自身免疫性疾病的一部分而被降解。通过酶联免疫吸附测定法（ELISA）检测111例患有各种结缔组织疾病的患者血清中针对原弹性蛋白和α-弹性蛋白的IgG抗体，与18名健康个体进行比较，以此来验证这种可能性。18例硬皮病患者血清中的抗α-弹性蛋白抗体显著高于健康对照组（p<0.008）。相反，硬皮病患者（p<0.03）以及患有各种其他结缔组织疾病的患者（p<0.02）的抗原弹性蛋白抗体水平低于健康对照组。硬皮病中针对天然弹性蛋白的抗体水平较低以及针对变性弹性蛋白的抗体水平较高，表明硬皮病中弹性蛋白的合成与降解比率较低。由于此前未被认识到的加速弹性蛋白溶解，硬皮病可能是弹性蛋白周转的独特模型。
