单剂量泼尼松龙治疗中度严重哮喘疗效欠佳。
Lack of efficacy of single-dose prednisolone in moderately severe asthma.
作者信息
Ho L, Landau L I, Le Souëf P N
机构信息
Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, WA.
出版信息
Med J Aust. 1994 Jun 6;160(11):701-4.
OBJECTIVE
To assess the effectiveness of single-dose prednisolone in reducing the length of illness and hospital stay in children admitted with moderately severe asthma.
DESIGN
A randomised, double-blind, controlled trial of a single dose of prednisolone in 64 children presenting with an acute attack of asthma with arterial oxygen saturation less than 93%.
RESULTS
No significant differences in the rate of recovery of oxygen saturation, lung function measurements or duration of hospital stay were found.
CONCLUSIONS
This study failed to confirm the benefit of a single dose of prednisolone in the management of children with acute severe asthma.
目的
评估单剂量泼尼松龙对减轻中度重症哮喘患儿疾病持续时间和住院时间的有效性。
设计
一项随机、双盲、对照试验，对64名动脉血氧饱和度低于93%的哮喘急性发作患儿使用单剂量泼尼松龙。
结果
在血氧饱和度恢复率、肺功能测量或住院时间方面未发现显著差异。
结论
本研究未能证实单剂量泼尼松龙对治疗急性重症哮喘患儿有益。
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