Mason R G, Wolf R H, Zucker W H, Shinoda B A, Mohammad S F
Am J Pathol. 1976 Jun;83(3):557-68.
The effects of aspirin, cyproheptadine, dextran, dipyridamole, and sulfinpyrazone on thrombus deposition were determined. These antithrombotic agents were evaluated in a nonhuman primate model for thrombus generation that employed test devices exposed to blood in an arteriovenous shunt. Thrombus deposition on test devices was quantitated gravimetrically. Of the antithrombotic agents tested, cyproheptadine was found to be the most effective, and aspirin, dextran, and dipyridamole were each somewhat less effective. Sulfinpyrazone had only a slight antithrombotic effect. Ultrastructual studies of thrombus deposited in test devices showed that the various antithrombotic agents tested did not prevent completely the formation of fibrin, aggregation of platelets, or adhesion and spreading of platelets and leukocytes. This model for thrombus generation is felt to be a more efficient means for evaluating antithrombotic agents than previously described nonhuman primate models.
测定了阿司匹林、赛庚啶、右旋糖酐、双嘧达莫和苯磺唑酮对血栓沉积的影响。在一种非人类灵长类动物血栓形成模型中对这些抗血栓药物进行评估，该模型使用暴露于动静脉分流血液中的测试装置。通过重量法对测试装置上的血栓沉积进行定量。在所测试的抗血栓药物中，发现赛庚啶最为有效，阿司匹林、右旋糖酐和双嘧达莫的效果稍差。苯磺唑酮只有轻微的抗血栓作用。对沉积在测试装置中的血栓进行的超微结构研究表明，所测试的各种抗血栓药物并不能完全阻止纤维蛋白的形成、血小板的聚集或血小板与白细胞的黏附及铺展。与先前描述的非人类灵长类动物模型相比，这种血栓形成模型被认为是评估抗血栓药物的更有效手段。
