Kogan A E, Bashkov G V, Bobruskin I D, Romanova E P, Makarov V A, Strukova S M
Eksp Klin Farmakol. 1994 Mar-Apr;57(2):42-5.
An antithrombotic action of the protein C (PC) activator from the venom of Agkistrodon blomhoffi ussuriensis on the model of platelet-dependent thrombosis in the arteriovenous shunt in rats was under investigation. Administration of the PC activator to rats resulted in a dose-dependent prolongation of the thrombus formation time, in a decrease in PC and factor V levels in blood and in APTT prolongation. There were no changes in the tissue-type plasminogen activator level and in the ADP- or epinephrine-induced platelet aggregation, but platelet adhesion to glass decreased. The possible mechanism of the antithrombotic action of the PC activator appeared to be the factor V inactivation mediated by protein C activation and the decrease in platelet adhesion.
正在研究来自乌苏里蝮蛇毒液的蛋白C（PC）激活剂对大鼠动静脉分流中血小板依赖性血栓形成模型的抗血栓作用。给大鼠施用PC激活剂导致血栓形成时间呈剂量依赖性延长，血液中PC和因子V水平降低以及活化部分凝血活酶时间（APTT）延长。组织型纤溶酶原激活剂水平以及二磷酸腺苷（ADP）或肾上腺素诱导的血小板聚集没有变化，但血小板与玻璃的粘附减少。PC激活剂抗血栓作用的可能机制似乎是由蛋白C激活介导的因子V失活以及血小板粘附的减少。
