de Sauvage F J, Hass P E, Spencer S D, Malloy B E, Gurney A L, Spencer S A, Darbonne W C, Henzel W J, Wong S C, Kuang W J
Department of Molecular Biology, Genentech, South San Francisco, California 94080.
Nature. 1994 Jun 16;369(6481):533-8. doi: 10.1038/369533a0.
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
生理状态下的血小板生成被认为需要巨核细胞集落刺激因子（meg-CSF）和血小板生成素的体液活性，它们分别促进巨核细胞的增殖和成熟。一种存在于受辐照猪血浆中的类巨核细胞集落刺激因子/血小板生成素蛋白已被纯化和克隆。这种蛋白与细胞因子受体超家族成员c-mpl蛋白结合并使之激活。分离出的Mpl配体与促红细胞生成素具有同源性，并能刺激巨核细胞生成和血小板生成。
