Salm E F, Egberts A C, Maartense E, Hart W, Stricker B H
Reinier de Graaf Gasthuis, afd. Interne Geneeskunde, Delft.
Ned Tijdschr Geneeskd. 1994 May 21;138(21):1080-2.
A 86-year-old woman became psychotic one day after starting treatment with 800 mg norfloxacin daily. Discontinuation and short-term treatment with haloperidol were followed by rapid disappearance of symptoms within two days. Since 1984, the Netherlands Centre for Monitoring of Adverse Reactions to Drugs received 19 similar reports of which 12 were attributed to norfloxacin, 3 to ofloxacin and 4 to pipemidic acid. The risk appears to be relatively high in the elderly, especially if they have fever, renal dysfunction and a psychiatric history. Lowering the doses may solve this problem provided the bacterial susceptibility is taken into account.
一名86岁女性在开始每日服用800毫克诺氟沙星治疗一天后出现精神错乱。停用诺氟沙星并使用氟哌啶醇进行短期治疗后，症状在两天内迅速消失。自1984年以来，荷兰药物不良反应监测中心收到了19份类似报告，其中12份归因于诺氟沙星，3份归因于氧氟沙星，4份归因于吡哌酸。这种风险在老年人中似乎相对较高，尤其是那些有发热、肾功能不全和精神病史的老年人。如果考虑到细菌敏感性，降低剂量可能会解决这个问题。
