Roy A, Dey S, Chatterjee R
Department of Tumor Virology, Chittaranjan National Cancer Institute, Calcutta, India.
Neoplasma. 1994;41(1):29-33.
Antibodies against Epstein-Barr virus capsid antigen (EBV-VCA) were measured in sera of Indian patients with respiratory tract carcinomas (lung, larynx, laryngopharynx, nasopharynx) using a commercial enzyme linked immunosorbent assay (ELISA) kit. Nineteen out of thirty-three (19/33) lung cancer, 12/22 laryngeal cancer, 11/16 laryngopharyngeal cancer, 6/9 nasopharyngeal carcinoma cases and 3/29 matched controls were positive for IgG antibody to VCA. None were positive for the IgM antibody to VCA. The antibody positivity was evaluated on the basis of immune status ratio (ISR) of the sera as described in the manual of the kit. Prevalence of the antibody was more pronounced among smokers with laryngeal and laryngopharyngeal carcinoma than among lung cancer cases. The results indicated that the antibody positivity rate among the patients declined with the advanced stages of the diseases. Serum IgG and IgM levels were raised in the patients who were tested positive for the viral antibody.
采用市售酶联免疫吸附测定（ELISA）试剂盒，检测印度呼吸道癌（肺癌、喉癌、喉咽癌、鼻咽癌）患者血清中抗爱泼斯坦-巴尔病毒衣壳抗原（EBV-VCA）的抗体。33例肺癌患者中有19例（19/33）、22例喉癌患者中有12例、16例喉咽癌患者中有11例、9例鼻咽癌患者中有6例以及29例匹配对照中有3例VCA IgG抗体呈阳性。VCA IgM抗体均为阴性。根据试剂盒说明书中所述的血清免疫状态比（ISR）评估抗体阳性情况。与肺癌患者相比，喉癌和喉咽癌吸烟者中抗体的患病率更为明显。结果表明，患者中的抗体阳性率随疾病进展阶段而下降。病毒抗体检测呈阳性的患者血清IgG和IgM水平升高。
