Handsfield H H, Wiesner P J, Holmes K K
Ann Intern Med. 1976 Jun;84(6):661-7. doi: 10.7326/0003-4819-84-6-661.
Ninety-eight patients with the gonococcal arthritis-dermatitis syndrome were prospectively treated with penicillin G, at least 10 million units intravenously per day, followed by ampicillin, 2.0 g orally per day, to complete at least 10 days of treatment (33 patients); ampicillin, 3.5 g orally plus probenecid 1.0 g, followed by ampicillin, 2.0 g per day orally for at least 7 days (29 patients); lower doses of parenteral penicillin G (20 patients); oral tetracycline (6 patients); parenteral cephalosporins (5 patients); and other regimens (5 patients). The response to treatment was equally rapid and complete in each group. At least 90% of the patients in each group had subjective improvement and defervescence within 2 days, and all patients followed for at least 2 weeks achieved complete clinical and bacteriologic cure. Patients with purulent synovial effusions improved significantly more slowly than patients with nonpurulent effusions or with no effusions, regardless of which treatment was used.
对98例淋菌性关节炎-皮炎综合征患者进行了前瞻性治疗，其中33例患者每天静脉注射至少1000万单位青霉素G，随后每天口服2.0克氨苄西林，疗程至少10天；29例患者每天口服3.5克氨苄西林加1.0克丙磺舒，随后每天口服2.0克氨苄西林至少7天；20例患者使用较低剂量的静脉注射青霉素G；6例患者口服四环素；5例患者使用静脉注射头孢菌素；5例患者采用其他治疗方案。每组对治疗的反应同样迅速且彻底。每组中至少90%的患者在2天内主观症状改善且体温下降，所有随访至少2周的患者均实现了临床和细菌学的完全治愈。无论采用何种治疗方法，有脓性滑膜积液的患者比无脓性积液或无积液的患者改善得明显更慢。
