Ratto G B, Mereu C, Rovida S
Department of Surgical Pathology, University of Genoa, Italy.
Panminerva Med. 1993 Dec;35(4):186-92.
The present prospective study has been carried out to evaluate the role of tumour markers in the preoperative assessment and follow-up of patients with potentially resectable lung cancer. The carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and tissue polypeptide antigen (TPA) have been preoperatively measured in 133 lung cancer patients and in 75 healthy smokers. The same tumour markers have been serially determined during the 12 to 30 month-follow-up of 53 subjects who had a complete resection. In screening for localized lung cancer, TPA determination was the single most accurate diagnostic test. The combined measurement of several tumour markers did not result in a greater diagnostic accuracy of the assay. In predicting lung cancer unresectability, CEA, though being the most suitable test, allowed preoperative detection of only one third of patients with unremovable tumours. In monitoring the postresectional course of subjects who had a complete resection, the combined measurement of TPA and NSE proved to be a very reliable predictor of disease recurrence.
本前瞻性研究旨在评估肿瘤标志物在潜在可切除肺癌患者术前评估及随访中的作用。对133例肺癌患者和75例健康吸烟者术前检测癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）和组织多肽抗原（TPA）。对53例接受完整切除的患者在12至30个月的随访期间连续检测相同的肿瘤标志物。在筛查局限性肺癌时，TPA测定是最准确的单项诊断试验。联合检测多种肿瘤标志物并未提高检测的诊断准确性。在预测肺癌不可切除性方面，CEA虽是最合适的检测指标，但仅能在术前检测出三分之一无法切除肿瘤的患者。在监测接受完整切除患者的术后病程时，TPA和NSE联合检测被证明是疾病复发非常可靠的预测指标。
