Suppr超能文献

在具有线粒体DNA(kDNA)序列缺失和重复的马媾疫锥虫(ATCC 30019)中,线粒体转录本会进行加工,但不能正常编辑。

Mitochondrial transcripts are processed but are not edited normally in Trypanosoma equiperdum (ATCC 30019) which has kDNA sequence deletion and duplication.

作者信息

Shu H H, Stuart K

机构信息

Seattle Biomedical Research Institute, WA 98109.

出版信息

Nucleic Acids Res. 1994 May 11;22(9):1696-700. doi: 10.1093/nar/22.9.1696.

Abstract

Analyses of the Trypanosoma equiperdum (ATCC 30019) maxicircle reveals deletions, duplications and rearrangement compared to T. brucei. The genes for 9S rRNA and 12 proteins are absent. The 12S rRNA and cytochrome oxidase subunit I (COI) genes lack their 3' ends and are adjacent indicating deletion of intervening genes. The remaining two NADH dehydrogenase subunit genes (ND4 and ND5), the ribosomal protein RPS12 gene and the CR5 gene are duplicated and rearranged. ND4, RPS12 and the CR4 transcripts are abundant in steady state RNA while 12S rRNA and COI transcripts are not detected. Full length ND5 transcripts are rare, if present, but chimeric ND5/ND4 transcripts are abundant. The CR4 and RPS12 transcripts are the size of unedited RNAs suggesting that they are processed. However, they are not edited normally, presumably due to the absence of minicircle gRNA genes.

摘要

与布氏锥虫相比,马媾疫锥虫(ATCC 30019)的大环分析显示存在缺失、重复和重排。9S rRNA和12种蛋白质的基因缺失。12S rRNA和细胞色素氧化酶亚基I(COI)基因缺少3'端且相邻,表明中间基因缺失。其余两个NADH脱氢酶亚基基因(ND4和ND5)、核糖体蛋白RPS12基因和CR5基因发生了重复和重排。ND4、RPS12和CR4转录本在稳态RNA中丰富,而未检测到12S rRNA和COI转录本。全长ND5转录本很少见(如果存在的话),但嵌合的ND5/ND4转录本丰富。CR4和RPS12转录本的大小与未编辑的RNA相同,表明它们经过了加工。然而,它们没有正常编辑,可能是由于缺少小环gRNA基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0de/308051/7c7f53372513/nar00033-0197-a.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验