Holy T E, Leibler S
Department of Physics, Princeton University, NJ 08544.
Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5682-5. doi: 10.1073/pnas.91.12.5682.
During the formation of the mitotic spindle, dynamic microtubules search for chromosomes in the surrounding cytosol. The average time required to reach such "targets" is calculated within a simple model of dynamic instability. The values of the dynamic parameters that minimize this search time are also obtained. The results approximate well observations of the capture of chromosomes in prometaphase cells. Compared to usual reversible polymerization, dynamic instability reduces the time required to find a target by several orders of magnitude.
在有丝分裂纺锤体形成过程中，动态微管在周围细胞质中搜寻染色体。在动态不稳定性的简单模型内计算到达此类“目标”所需的平均时间。还获得了使该搜寻时间最小化的动态参数值。结果与前中期细胞中染色体捕获的观察结果吻合良好。与通常的可逆聚合相比，动态不稳定性将找到目标所需的时间减少了几个数量级。
