Woodruff J M, Perino G
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Semin Diagn Pathol. 1994 Feb;11(1):69-81.
Non-germ-cell or teratomatous malignant tumors showing additional rhabdomyoblastic differentiation can be divided into three groups. Group I consists of tumors with only sarcomatous differentiation. Included in this group are malignant mesenchymoma, dedifferentiated chondrosarcoma, and the dedifferentiated retroperitoneal liposarcoma. Epithelial or Sertoli-Leydig cell elements represent the second component of tumors in group II. The best known tumor in this group is the malignant mullerian mixed tumor, but other well described tumors with rhabdomyosarcomatous differentiation are the carcinosarcoma, mullerian adenosarcoma, Sertoli-Leydig cell tumor, mammary cystosarcoma, and blastomas. Most of the tumors in groups I and II are derived from mesenchymal tissue. A neuroectodermal origin is shared by all tumors in group III. This includes the medulloblastoma, retinoblastoma and, most frequently, the malignant Triton tumor. The tumors in all three groups are clinically malignant to a varying degree.
显示额外横纹肌母细胞分化的非生殖细胞或畸胎瘤性恶性肿瘤可分为三组。第一组由仅具有肉瘤样分化的肿瘤组成。该组包括恶性间叶瘤、去分化软骨肉瘤和去分化腹膜后脂肪肉瘤。上皮或支持-莱迪希细胞成分是第二组肿瘤的第二个组成部分。该组中最著名的肿瘤是恶性苗勒管混合瘤，但其他有充分描述的具有横纹肌肉瘤样分化的肿瘤有癌肉瘤、苗勒管腺肉瘤、支持-莱迪希细胞瘤、乳腺囊肉瘤和成神经细胞瘤。第一组和第二组中的大多数肿瘤起源于间充质组织。第三组中的所有肿瘤都起源于神经外胚层。这包括髓母细胞瘤、视网膜母细胞瘤，最常见的是恶性蝾螈瘤。所有三组中的肿瘤在临床上都有不同程度的恶性。
