Cuijpers C E, Swaen G M, Wesseling G, Wouters E F
Department of Epidemiology, University of Limburg, Maastricht, The Netherlands.
Toxicol Lett. 1994 Jun;72(1-3):227-35. doi: 10.1016/0378-4274(94)90033-7.
In 535 primary school children we studied the effects of exposure to summer smog on respiratory health. Baseline measurements were performed during low air pollution levels (max. 24-h concentrations of SO2, O3 and NO2 were 55, 49 and 58 micrograms/m3, respectively) consisting of lung function measurements using spirometry and the forced oscillation technique (FOT) and the prevalence of respiratory symptoms, determined by a written questionnaire. During a summer smog episode, 212 randomly chosen children were re-examined, characterised by 8-h ozone levels > 120 micrograms/m3 (max. 163 micrograms/m3) and 1-h ozone levels > 160 micrograms/m3 (max. 215 micrograms/m3). Overall, small decrements were observed in the forced expiratory volume in 1 s (FEV1), (P < 0.05) and the forced expiratory volume between 25 and 75% of the vital capacity (FEF25-75%) (P < 0.01). On the contrary, there was a statistically significant decrease in resistance parameters. No increases were observed in the prevalence of acute respiratory symptoms. In conclusion, in this study we found small inconsistent changes in lung function and no increase of respiratory symptoms after short-time exposure to moderately high ozone levels.
在535名小学生中，我们研究了暴露于夏季烟雾对呼吸健康的影响。在低空气污染水平期间（二氧化硫、臭氧和二氧化氮的24小时最高浓度分别为55、49和58微克/立方米）进行基线测量，包括使用肺活量测定法和强迫振荡技术（FOT）进行肺功能测量，以及通过书面问卷确定呼吸道症状的患病率。在一次夏季烟雾事件期间，对212名随机选择的儿童进行了重新检查，其特征为8小时臭氧水平>120微克/立方米（最高163微克/立方米）和1小时臭氧水平>160微克/立方米（最高215微克/立方米）。总体而言，观察到1秒用力呼气量（FEV1）（P<0.05）和肺活量25%至75%之间的用力呼气量（FEF25-75%）（P<0.01）出现小幅下降。相反，阻力参数有统计学意义的下降。急性呼吸道症状的患病率没有增加。总之，在本研究中，我们发现短期暴露于中度高臭氧水平后，肺功能有小的不一致变化，呼吸道症状没有增加。
