González E, Ledesma de Paolo M I, Celener D, Celener F P, Rosembeck G, Panzitta M T, Bustos Fernández L
Instituto de Gastroenterología Dr Jorge Perez Companc, Buenos Aires, Argentina.
Acta Gastroenterol Latinoam. 1993;23(4):203-10.
Depending on quantity and/or quality, the presence of lactic acid in the colonic lumen may be associated with metabolic damage of the colon. The influence exerted on the rat colon by the different isomers and racemic of the lactic acid, used at two extreme dilutions (20 and 100 mEq/l), has been the subject of study in this paper. The modifications on pH, water and electrolytes are associated with the absorptive/secretory action of the colonic wall. In addition, a study has been made on the influence of lactic acid on the colonic mucus and albumin permeation. Histopathologic studies of the caecum and left colon have been performed. There is a different colonic wall behaviour for each of the different isomers of the lactic and its racemic; a larger absorption of water, Na+ and Cl- for the D (-) isomer at a low concentration; its behaviour is completely opposite at high concentration. The final pH is higher when the D (-) isomer takes part; comparing the different isomers, there are small variations as far as albumin permeation is concerned. At high concentration there is a decline in Cl- absorption. The high percentage of erosions that take place especially in the caecum, where L (+) isomer can be found at high concentration, it is remarkable. The present observations suggest that the presence of lactic acid in (the) ulcerative colitis deserves great attention, especially in about the quantity and quality in which the acid can be found.
根据数量和/或质量的不同，结肠腔内乳酸的存在可能与结肠的代谢损伤有关。本文研究了两种极端稀释度（20和100 mEq/l）下不同乳酸异构体和外消旋体对大鼠结肠的影响。pH值、水和电解质的变化与结肠壁的吸收/分泌作用相关。此外，还研究了乳酸对结肠黏液和白蛋白渗透的影响。对盲肠和左结肠进行了组织病理学研究。乳酸的不同异构体及其外消旋体对结肠壁的作用各不相同；低浓度时D（-）异构体对水、Na+和Cl-的吸收更大；高浓度时其行为则完全相反。当D（-）异构体参与时，最终pH值更高；就白蛋白渗透而言，比较不同异构体时存在微小差异。高浓度时Cl-吸收下降。尤其是在盲肠中发生的高比例糜烂现象很显著，在盲肠中可发现高浓度的L（+）异构体。目前的观察结果表明，溃疡性结肠炎中乳酸的存在值得高度关注，特别是酸的数量和质量。
