Prellner K, Foglé-Hansson M, Jørgensen F, Kalm O, Kamme C
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Acta Otolaryngol. 1994 Mar;114(2):182-7. doi: 10.3109/00016489409126039.
The question whether penicillin V (pcV) given intermittently upon signs of upper respiratory tract infections (URTI) in otitis-prone children might prevent recurrent bouts of acute purulent otitis media (AOM) is addressed. As compared with continuous long-term antibiotic treatment as prophylaxis in otitis-prone children, intermittent administration would reduce the overall consumption of antibiotics. Seventy-six otitis-prone children less than 18 months of age were included in this double-blind, randomized, placebo-controlled multicentre study. Follow-up was from January till June. One hundred and twenty-three episodes of AOM occurred. The number of AOM episodes was reduced by 50% in the children on pcV during URTI episodes as compared with those on placebo. No obvious ecological drawbacks were noted. Thus, the described mode of pcV administration seems to be a rational and safe way to reduce the number of AOM episodes in otitis-prone children.
本文探讨了对于易患中耳炎的儿童，在出现上呼吸道感染（URTI）症状时间歇性给予青霉素V（pcV）是否可以预防急性化脓性中耳炎（AOM）反复发作的问题。与在易患中耳炎的儿童中采用连续长期抗生素治疗作为预防措施相比，间歇性给药可减少抗生素的总体消耗量。本双盲、随机、安慰剂对照的多中心研究纳入了76名18个月以下易患中耳炎的儿童。随访时间为1月至6月。共发生123次AOM发作。与服用安慰剂的儿童相比，在URTI发作期间服用pcV的儿童AOM发作次数减少了50%。未发现明显的生态学缺陷。因此，所描述的pcV给药方式似乎是减少易患中耳炎儿童AOM发作次数的一种合理且安全的方法。
