Onitsuka T
Department of Otolaryngology, School of Medicine, Nagasaki University, Japan.
Acta Otolaryngol. 1994 Mar;114(2):218-22. doi: 10.3109/00016489409126046.
This is a histologic study using the peroxidase-antiperoxidase (PAP) method for demonstration of estradiol, testosterone, dihydrotestosterone and progesterone in the normal thyroid gland and papillary carcinoma of the thyroid gland as well as in the normal parotid gland and pleomorphic adenomas. The results show that the normal follicular epithelia of the thyroid gland and the intercalated, striated ducts in the parotid gland stained for sex hormones. Estradiol was positive in both thyroid and parotid gland tissue in females and males. In females, testosterone and dihydrotestosterone were not recognized in the thyroid gland tissue and were only weakly present or negative in parotid gland tissue. In males, both testosterone and dihydrotestosterone were positive. Papillary carcinoma of the thyroid gland and pleomorphic adenoma of the parotid gland were positive for estradiol but not for testosterone or dihydrotestosterone. This suggests that there is a sex difference in the influence of sex hormones on the normal thyroid and parotid glands, and that estradiol exerts an influence on papillary carcinoma of the thyroid gland and pleomorphic adenoma of the parotid gland.
这是一项组织学研究，采用过氧化物酶-抗过氧化物酶（PAP）法来显示正常甲状腺和甲状腺乳头状癌以及正常腮腺和多形性腺瘤中的雌二醇、睾酮、双氢睾酮和孕酮。结果显示，甲状腺的正常滤泡上皮以及腮腺中的闰管、纹状管对性激素呈阳性染色。雌二醇在女性和男性的甲状腺及腮腺组织中均呈阳性。在女性中，甲状腺组织未检测到睾酮和双氢睾酮，腮腺组织中仅微弱存在或呈阴性。在男性中，睾酮和双氢睾酮均呈阳性。甲状腺乳头状癌和腮腺多形性腺瘤对雌二醇呈阳性，但对睾酮或双氢睾酮呈阴性。这表明性激素对正常甲状腺和腮腺的影响存在性别差异，且雌二醇对甲状腺乳头状癌和腮腺多形性腺瘤有影响。
