一项针对儿童的新型口服人造黄油负荷试验。

A new oral margarine loading test in children.

作者信息

Shimizu T, Yamashiro Y, Yabuta K

机构信息

Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Acta Paediatr Jpn. 1994 Apr;36(2):183-5. doi: 10.1111/j.1442-200x.1994.tb03158.x.

DOI:10.1111/j.1442-200x.1994.tb03158.x

PMID:8203264

Abstract

Margarine (2g/kg) was orally administered to 39 children with normal fat digestion and absorption (control group) and 17 children with abnormal fat digestion and absorption (malabsorbed group). The serum triglyceride (TG) level was serially determined by capillary blood sampling. In the control group, the TG level was significantly elevated after 2, 3 and 4 h as compared with the level before margarine ingestion (basal TG). The maximum TG elevation rate [MTER = (maximum TG-basal TG)/basal TG x 100] was > 50% in all but three children. In contrast, a significant increase in TG was not observed in the malabsorbed group after margarine ingestion, and the MTER was < 50% in all but two children. The MTER was significantly lower in children with a high microscopic score of fecal fat than that in children with a low score. This oral margarine loading test is a simple and semi-quantitative evaluation of fat digestion and absorption, and is considered to be useful for the assessment of the presence or severity of fat maldigestion and malabsorption in children.

摘要

向39名脂肪消化吸收正常的儿童（对照组）和17名脂肪消化吸收异常的儿童（吸收不良组）口服给予人造黄油（2g/kg）。通过采集毛细血管血连续测定血清甘油三酯（TG）水平。在对照组中，与摄入人造黄油前的水平（基础TG）相比，2、3和4小时后的TG水平显著升高。除3名儿童外，所有儿童的最大TG升高率[MTER =（最大TG - 基础TG）/基础TG×100]均>50%。相比之下，吸收不良组在摄入人造黄油后未观察到TG显著升高，除2名儿童外，所有儿童的MTER均<50%。粪便脂肪显微镜评分高的儿童的MTER显著低于评分低的儿童。这种口服人造黄油负荷试验是一种简单的脂肪消化吸收半定量评估方法，被认为有助于评估儿童脂肪消化和吸收不良的存在或严重程度。