Fauvelle F, Perrin P, Belfayol L, Boukari M, Cherrier P, Bosio A M, Tod M, Coulaud J M, Petitjean O
Laboratory of Clinical Pharmacy, Montfermeil Hospital, France.
Antimicrob Agents Chemother. 1994 Mar;38(3):620-3. doi: 10.1128/AAC.38.3.620.
Netilmicin (4.5 mg/kg of lean body weight) was administered intravenously once every 24 h at 10 a.m. to 23 patients (group I) and at 10 p.m. to 20 patients (group II) with severe infection. No significant differences (P > 0.05) in peak and trough concentrations in serum were found between groups I and II (peak, 12.9 +/- 3.7 versus 12.8 +/- 4.4 mg/liter, respectively; trough, 0.7 +/- 0.6 versus 0.8 +/- 0.6 mg/liter, respectively [mean +/- standard deviation]). Pharmacokinetic parameters (half-life [5.0 +/- 2.2 versus 4.9 +/- 1.8 h], volume of distribution [0.32 +/- 0.04 versus 0.35 +/- 0.06 liter/kg], and total clearance [0.920 +/- 0.417 versus 1.015 +/- 0.546 ml/min/kg]) were similar in the two groups and not influenced by the time of administration. These data suggest that, in the once-daily schedule, 10 a.m. or 10 p.m. administration had no influence on netilmicin levels in serum and pharmacokinetic parameters in these ill febrile patients.
对23例严重感染患者（I组）于上午10点静脉注射奈替米星（4.5mg/kg瘦体重），每24小时1次；对20例严重感染患者（II组）于晚上10点静脉注射奈替米星（4.5mg/kg瘦体重），每24小时1次。I组和II组血清峰浓度和谷浓度无显著差异（P>0.05）（峰浓度分别为12.9±3.7与12.8±4.4mg/L；谷浓度分别为0.7±0.6与0.8±0.6mg/L[均值±标准差]）。两组的药代动力学参数（半衰期[5.0±2.2与4.9±1.8小时]、分布容积[0.32±0.04与0.35±0.06L/kg]及总清除率[0.920±0.417与1.015±0.546ml/min/kg]）相似，且不受给药时间影响。这些数据表明，在每日1次给药方案中，上午10点或晚上10点给药对这些发热患者的血清奈替米星水平和药代动力学参数无影响。
