Thacker J, Baker N V
Br J Radiol. 1976 Apr;49(580):367-371. doi: 10.1259/0007-1285-49-580-367.
Flies of the species Drosophila melanogaster have been irradiated with 1 MHz ultrasound at intensities of 0-05-2 W cm-2. The flies were immersed in water and rotated in the ultrasound field to ensure that they were adequately exposed to the radiation. Immersion and rotation alone were not found to impair subsequent survival and fertility of the flies. At the higher intensities of irradiation, the flies were found to be killed in direct proportion to the duration of the irradiation. However, large-scale breeding experiments with flies surviving irradiation showed that no significant increase in the frequency of recessive lethal mutation (Muller 5 system) and chromosomal non-disjunction (Clark-Sobels system) had occurred. Taken with other recent studies, this result suggests there is little risk of genetic damage to multicellular organisms from ultrasound irradiations at frequencies and intensities currently used in medical practice.
已用强度为0.05 - 2瓦/平方厘米的1兆赫超声波辐照黑腹果蝇。果蝇被浸入水中并在超声场中旋转，以确保它们充分暴露于辐射中。仅浸入和旋转未发现会损害果蝇随后的存活率和繁殖力。在较高的辐照强度下，发现果蝇的死亡与辐照持续时间成正比。然而，对辐照后存活的果蝇进行的大规模繁殖实验表明，隐性致死突变（穆勒5系统）和染色体不分离（克拉克 - 索贝斯系统）的频率没有显著增加。结合其他近期研究，该结果表明，按照目前医学实践中使用的频率和强度进行超声辐照，对多细胞生物体造成遗传损伤的风险很小。
