Lawhorn C D, Boop F, Brown R, Andelman P
Arkansas Children's Hospital, Little Rock 72202-3591.
Pediatr Neurosurg. 1994;20(3):198-202. doi: 10.1159/000120788.
The authors report a randomized double-blind prospective study comparing epidural morphine 80 micrograms/kg to epidural morphine 80 micrograms/kg plus butorphanol 40 micrograms/kg in children undergoing rhizotomy. Up to 50% of children receiving epidural morphine alone will experience side effects of nausea, vomiting, pruritus, urinary retention or respiratory depression. The addition of the narcotic agonist-antagonist butorphanol virtually eliminated these side effects without compromising analgesia or causing undue sedation. Parent satisfaction was greater than 90%.
作者报告了一项随机双盲前瞻性研究,该研究比较了在接受神经根切断术的儿童中,硬膜外注射80微克/千克吗啡与硬膜外注射80微克/千克吗啡加40微克/千克布托啡诺的效果。单独接受硬膜外吗啡的儿童中,高达50%会出现恶心、呕吐、瘙痒、尿潴留或呼吸抑制等副作用。添加麻醉激动剂-拮抗剂布托啡诺几乎消除了这些副作用,同时不影响镇痛效果或导致过度镇静。家长满意度超过90%。