惊恐障碍患者与健康对照者血小板3H-帕罗西汀和3H-丙咪嗪结合的比较研究。
Comparative study of platelet 3H-paroxetine and 3H-imipramine binding in panic disorder patients and healthy controls.
作者信息
Faludi G, Tekes K, Tóthfalusi L
机构信息
Semmelweis Medical University, Department of Psychiatry, Budapest, Balassa, Hungary.
出版信息
J Psychiatry Neurosci. 1994 Mar;19(2):109-13.
Abstract
High affinity 3H-paroxetine and 3H-imipramine binding sites were simultaneously studied in platelets of 29 untreated patients with panic disorder and 12 healthy controls. The maximum number of binding sites (Bmax) was found to be significantly lower in the panic patients compared to the controls using either ligand. No difference in the Kd values between the groups of subjects was found. The disturbance of serotonin neurotransmission in panic disorder--decrease in Bmax values--may be either a consequence or a reason of serotonergic dysfunction.
摘要
在29名未经治疗的恐慌症患者和12名健康对照者的血小板中，同时研究了高亲和力的3H-帕罗西汀和3H-丙咪嗪结合位点。使用任何一种配体时，发现恐慌症患者的结合位点最大数量（Bmax）显著低于对照组。两组受试者之间的解离常数（Kd）值没有差异。恐慌症中5-羟色胺神经传递的紊乱——Bmax值降低——可能是5-羟色胺能功能障碍的结果或原因。
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