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透明隔畸形:两例与精神分裂症相关的独特病例。

Malformations of the septum pellucidum: two distinctive cases in association with schizophrenia.

作者信息

Wolf S S, Hyde T M, Weinberger D R

机构信息

Division of Intramural Research Programs, NIMH Neuroscience Center at St. Elizabeths, Washington, DC 20032.

出版信息

J Psychiatry Neurosci. 1994 Mar;19(2):140-4.

Abstract

Two patients with schizophrenia had markedly abnormal neuroimaging studies; one was found to have a large, cystic cavum vergae, while the other demonstrated complete agenesis of the septum pellucidum with a monoventricular system. The increased prevalence of developmental abnormalities of midline forebrain structure in patients with schizophrenia suggests that dysgenesis of these structures may be contributory to the neurobiology of schizophrenia and other psychotic disorders.

摘要

两名精神分裂症患者的神经影像学研究结果明显异常;其中一名被发现有一个大的、囊性的透明隔腔,而另一名则表现为透明隔完全缺如并伴有单脑室系统。精神分裂症患者中线前脑结构发育异常的患病率增加,这表明这些结构的发育异常可能是精神分裂症和其他精神障碍神经生物学的一个促成因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cc3/1188578/7facaf88ba5f/jpn00054-0064-a.jpg

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